The decomposition of the blood Hemolysis:
The breaking of red blood cells by the decomposition of the blood occur within vivo Invivo and Invitro as well as in vitro and this process can be carried out under conditions of several cases, including:
1. osmosis Osmotically:
Because the membrane hateful red allows the entry into force of the water, the cell size varies depending on the change in the middle osmotic If you put the pellets in a low solution tension Hypotonic the water will be implemented into the cell and bloom the cell and changing recipes membrane arise by minute channels allow the passage of hemoglobin and other cell contents are scattered in the ocean of liquid cells.
2 - analyzes the blood gets sick in the following cases:
A - anemia or acute blood Hemolytic Anemia poverty as well as in the case of jaundice in newborns Jaundice
B - the sudden increase hemoglobin in the urine Paroxysmal Hemoglobinuria
3 - decomposition of blood resulting from eating certain drugs:
Some drugs cause lysis of red blood cells such as quinine Quinine and Alvenaseaton Phenacetin Nitrites and nitrates and chlorates Chlorates.
4 - fatty solvents:
Such as alcohol, ether, chloroform and some materials such as soap and yellow material and salts saponins Saponin This material melts the fat in the hated red or change the order of fat particles trends in the membrane cell membrane.
5 - mechanical methods:
Mechanical methods play an important role negative impact on the different samples a private blood samples and these methods milling Grinding, stirring Stirring or severe shaking Shaking as well Repeated freezing and Aeltsiih Thawing.
That there are some other factors that lead to blood decomposition in the pipe, such as the change in temperature, pH and exposure to ultraviolet light, and the concentration of serum components concentration of hemoglobin in sickle cell sample is affected by more than 20 mg / 100 ml, as there are two degrees of decomposition of the blood sample mild first Slightly Hemolysis and this effect a few most of the chemical analyzes, and the second type is a severe decomposition of the blood Server Hemolysis, which affects the ease components that are no little concentration inside the red blood cells more than its effect on the components in the plasma (where severe decomposition leads to an increase items in the inside cells relative to the outside of cells and increase its focus such as sodium and potassium, an enzyme LDH ... etc.) on the whole, the clear effect can be seen on the ingredients found in the plasma of this, the concentration in plasma increases in decomposing the sample in the following tests enzyme Aloldollaz Aldolase enzyme alkaline phosphatase enzyme LDH enzyme Aizostreet disputed hydrogen, potassium, Almjneziom, phosphate and grow as well as phosphate inorganic in serum as rapidly as organic Aster located inside cells that are decomposed, as well as increasing dynamism enzymatically amino transferase (GOT, GPT) by 2% for every 10 mg / 100 ml resulting from the increase in hemoglobin concentration as well as the LDH enzyme increases by about 10% for every 10 mg / 100 ml of hemoglobin, and we can see a sample of blood decaying looking at it with the naked eye.
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